منابع مشابه
Tissue-specific insulin resistance.
T he combination of abnormal glucose tolerance, central adiposity, dyslipidaemia, hypertension, and coronary artery disease is together referred to as the metabolic syndrome or the insulin resistance syndrome. A sedentary lifestyle, polygenic inheritance, and abnormal intrauterine programming are but some of the hypotheses put forward to explain the syndrome, the central underlying feature of w...
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Insulin resistance in skeletal muscle and liver may play a primary role in the development of type 2 diabetes mellitus, and the mechanism by which insulin resistance occurs may be related to alterations in fat metabolism. Transgenic mice with muscle- and liver-specific overexpression of lipoprotein lipase were studied during a 2-h hyperinsulinemic-euglycemic clamp to determine the effect of tis...
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Although insulin regulates metabolism in both brown and white adipocytes, the role of these tissues in energy storage and utilization is quite different. Recombination technology using the Cre-loxP approach allows inactivation of the insulin receptor in a tissue-specific manner. Mice lacking insulin receptors in brown adipocytes show an age-dependent loss of interscapular brown fat but increase...
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Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294 Department of Nutrition, University of Alabama at Birmingham, Birmingham, AL 35294 ...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 2004
ISSN: 0032-5473
DOI: 10.1136/pgmj.2004.023176